In a photo from "Here Comes the Flood," Alex, Meredith and Izzie listen to the Chief lecture. What could he be talking to them about?

Derek and Izzie in a photo from "Brave New World," from the fifth season of Grey's Anatomy.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," and in every episode of Grey's Anatomy, Izzie is unmistakable. She's the best ... but also always close to trouble.

She's our girl. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," a lot of people will be wondering if this is the last season for Izzie Stevens (Katherine Heigl).

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Stevens is seen with some of Seattle Grace's newest patients.

Izzie Stevens attends to a car crash victim (or so it would appear) in the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me."

It looks like that's about to happen in the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," which we see a scene from here.

At least Izzie seems to be. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Stevens and other doctors at Seattle Grace stand outside. What will happen next?!

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," five of our favorite Seattle Grace staff members stand outside. Something tells us something bad is going to happen.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," four of our favorite Seattle Grace staff members stand outside their place of employment.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Izzie helps a trauma patient out of the car. Looks intense!

Don't count on it, according to some of the Grey's Anatomy spoilers we've read.