Alex and Izzie don't know what the best course of action is going forward, and it's hard to blame them.

Izzie and Alex embrace in the fifth season finale.

Izzie Stevens may be bald, but she's still hot in the eyes of Alex Karev, and all of us.

Meredith tries to help Izzie remember images while Derek runs tests.

Has Izzie Stevens passed away? If that is what we are supposed to take away from the powerful scene at the end, it was certainly emotionally devastating, but great television.

Alex tends to ailing Izzie in an emotional Season Five scene from Grey's Anatomy. These two have become bigger and bigger characters since the series debuted.

Alex and Izzie are husband and wife.

Alex and Izzie embrace after getting married in the wedding of her dreams - which she originally planned for Meredith!

Izzie Stevens in "What a Difference a Day Makes," the 100th episode of Grey's Anatomy. She is about to get married to Alex. Sniff.

Alex Karev kisses new wife Izzie Stevens after an emotional exchange of vows and her dream wedding coming to fruition - even though she never intended to be the bride. Bet she's glad she is now!

Alex and Izzie got married in "What a Difference a Day Makes," the 100th episode of Grey's Anatomy. It was a great scene and a great episode.

That was the climactic scene of the 100th episode of Grey's Anatomy - the surprise nuptials of Alex and Izzie. Meredith and Derek were the ones supposedly getting married this day!