McD in Charge

McD in Charge

Derek asks questions in "I Saw What I Saw." Hopefully someone can get to the bottom of what happened.
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A Funny Scene

A Funny Scene

A funny scene from "I Always Feel Like Somebody's Watchin' Me," from the sixth season of Grey's Anatomy. There's some serious baseball going on!
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Mark Sloan, M.D.

Mark Sloan, M.D.

Mark Sloan (Eric Dane) is one of many hot and emotionally challenged doctors at Seattle Grace. But he's come a long way since dating Lexie.
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Mexie Pic

Mexie Pic

Mark and Lexie smile and cheer at the wedding of Alex and Izzie. These two have become a hot couple here in Season Five!
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Doing Lexie

Doing Lexie

Mark finally admits this fact, and ends up getting punched. Possibly a bit of an overreaction on Derek's part.
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Maddison and Archer

Maddison and Archer

Mark and Addison used to have a thing. Now the only thing they are worried about is saving her brother's life.
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Mark and Naomi

Mark and Naomi

Mark and Naomi converse in a scene from "Before and After," from Season Five of Grey's Anatomy.
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Sending a Signal

Sending a Signal

We all know what that look Lexie is shooting Mark says. Or at least we think we do. The episode will prove it one way or the other.
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Going Public?

Going Public?

Will Mark and Lexie go public with their relationship? Do people like their relationship? We don't know, but it will be interesting to find out.
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Callie, Mark and Lexie

Callie, Mark and Lexie

A nice picture of Callie, Lexie and Mark at the bar in "Beat Your Heart Out," from the fifth season of Grey's Anatomy.
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Derek Observes Mark and Lexie

Derek Observes Mark and Lexie

Derek looks on as Mark and Lexie gaze upon each other in "Beat Your Heart Out," from the fifth season of Grey's Anatomy.
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Mexie Love

Mexie Love

Mark and Lexie in "Beat Your Heart Out," from the fifth season of Grey's Anatomy.
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Grey's Anatomy Quotes

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)