Cameron took over Cuddy's job for the episode titled "Big Baby." This change didn't last long, however.

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Show:
House
Episode:
House Season 5 Episode 13: "Big Baby"
Character:
Allison Cameron
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House Season 5 Episode 13 Quotes

Kutner: Cameron's in charge?
Thirteen: When did that happen.?
Kutner: You're going to destroy her, aren't you?
House: I am going to do my job. If that involves leaving her a rotting pulp...

House: So why are you here?
Dr. Cameron: Because Dr. Cuddy is not here. She's decided to spend some more time at home with the baby for a while. I'm taking over some of her day-to-day responsibilities, like babysitting you.
House: Interesting. You have your whole life ahead of you, so why would Cuddy want you to die so young?
Dr. Cameron: She figured I' spent three years working for you. I was inoculated.
House: Good. Fun. You get to exercise your newfound power, I squirm under your thumb, resent the student becoming the teacher, and then push comes to shove, and we all get to realize what our real roles should be. Then you put out.
Dr. Cameron: That's why I took the job.