Living Without It - Family Guy
Quagmire's most treasured body part is cut off and he must figure out how to go one with it on Family Guy.

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Family Guy
Family Guy Season 16 Episode 19: "The Unkindest Cut"
Glenn Quagmire
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Family Guy Season 16 Episode 19 Quotes

Peter: Doc. Give it to us straight. What's going on with our friend?
Dr. Hartman: Well, Mr. Griffin, there's no easy way to put this, so I'm just going to come right out and say it. He's black.
Peter: Not that friend. Quagmire.
Dr. Hartman: Oh. Him.

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You don't know what that penis meant to me. We did everything together. Everything.