Meet the Quagmires Picture
When Peter goes back in time and messes things up with Lois, she ends up marrying Quagmire and having a Chris, Meg and Stewie that look like Quagmire instead.

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Show:
Family Guy
Episode:
Family Guy Season 5 Episode 18: "Meet The Quagmires"
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Family Guy Season 5 Episode 18 Quotes

Brian: You ever hear of the theory that if you kill a butterfly in the past, it can drastically alter the present? Well who knows what else we changed.
(Peter turns the TV on)
Announcer: Tonight on the Tonight Show, movie star George Clooney.
Peter: Oh, he's good.
Announcer: Comedian Dave Chappelle.
Brian: He's funny, like him.
Announcer: And musician Harry Connick Jr.
Peter: Wow, what a show.
Announcer: And now, ladies and gentleman, heeeeeeeeeere's Chevy!
Peter: Oh god Brian, we messed up bad! We messed up real bad!

Lois: Peter used to be so passionate, but now he doesn't seem to be interested in me.
Quagmire: Lois, if I may, Peter doesn't you. As a friend, I think you deserve to be with someone who knows how to be a gentleman.
Lois: Oh, Glen. You're so sweet. (They embrace) Something's poking me.
Quagmire: It's alright. It's just my wang.