Upset Meredith

After all that happens at Seattle Grace in this episode, one can certainly understand why Meredith would be upset.
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What to Do Next

Alex and Izzie don't know what the best course of action is going forward, and it's hard to blame them.
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Izzie and Husband

Izzie and Alex embrace in the fifth season finale.
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Hot, Bald Wife

Izzie Stevens may be bald, but she's still hot in the eyes of Alex Karev, and all of us.
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Flash Cards

Meredith tries to help Izzie remember images while Derek runs tests.
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Army Doctor O'Malley

George signs up for the Army, inspired by Hunt and by a patient named Charlie. But tragedy awaits him before he even ships out.
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John Doe

We now know who John Doe is, but didn't at the time.
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George in Uniform

Is this the last shot of George O'Malley we will see on Grey's Anatomy? If so, he had a terrific run, and we will miss him dearly.
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Izzie in the Afterlife?

Has Izzie Stevens passed away? If that is what we are supposed to take away from the powerful scene at the end, it was certainly emotionally devastating, but great television.
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DOA?

Is this patient going to be revived, or is it already too late?
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A MerDer Kiss

Derek kisses Meredith in the halls of Seattle Grace. Aww.
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Still the Best

Meredith and Derek are still the best, and have been from day one, as crazy as we've been about the show's many other pairings over the years.
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Grey's Anatomy Season 5 Quotes

[narrating] We all remember the bed time stories of our childhood. The shoe fit Cinderella, the frog was turned into a prince, sleeping beauty was awakened with a kiss. Once upon a time and then they lived happily ever after. Fairy tales. The stuff of dreams. the problem is, fairy tales don't come true. It's the other stories. The ones that start in dark and stormy nights and end in the unspeakable. The nightmares always seem to become the reality.

Meredith

Meredith: What happened!?
Cristina: A bus in front of him hit a telephone pole. He tried to swerve and miss it, but ...
Meredith: How bad is it?
Richard: Meredith -
Cristina: Meredith, you're gonna have to be strong.