Serena hooks up with Nate who is dating her best friend Blair

Nathan Scott was one of the stars, if not the biggest star, on the Tree Hill Ravens.

Nathan Scott and Haley James finally experience their first kiss outside of Haley's house.

Lucas and Peyton finally hook up. But Lucas scares her away when he admits that he's been wanting more than just a fling.

Nathan and Lucas are kidnapped by a rival team after Whitey throws them off the bus for fighting at a game. Guess who finds them?

OTH launched itself on the whole basketball aspect and how Lucas joining the team changed his future and his path. Additionally, Lucas joining the Ravens was the catalyst for change in all the other main characters, whether it was meeting, hooking up, friendships, changing perspectives, etc. -- Leigh Raines

Nathan and Dan Scott face off during the Tree Hill Ravens Father/Son game. Things get heated.

Lucas and Peyton at a post-game party. Welcome to the Scott beach house.

Haley and Lucas talk in the hallway at Tree Hill high school. Is Lucas enjoying his newfound popularity?

The original cast of One Tree Hill poses for this promotional photo on behalf of The WB.

Lucas and Nathan face off on the Rivercourt. They make a bet and Lucas wins.

Where does this moment rank among your most memorable on One Tree Hill? We said goodbye to Dan Scott on season nine.