Guns are down, so that's good. Sam and Dean must be asking about the president and if the Secret Service know if something weird has been going on with the president.
It looks like the Secret Service have their guns drawn. But what is Dean looking at from behind? Something more dangerous? Perhaps a President Lucifer?
When Lucifer decides he has no plan and no rules to follow, Crowley might be worried that Lucifer is going to come after him next. He doesn't look too pleased with his current conversation, so he hasn't found a way to take down the rogue villain.
Is Crowley meeting up with someone from the British Men of Letters? Another demon? Perhaps an angel? Either way, it looks like something serious is about to go down.