DEREK: "You really are Satan, you realize that right? If Satan were to take physical form he'd be you, everywhere. All the time."
ADDISON: "I am not Satan."
DEREK: "How come you haven't gotten on your broomstick and gone back to New York where you belong?"
ADDISON: "Stop being petty."
DEREK: "Stop being an adulterous bitch."
ADDISON: "You know there was a time when you though of me as your best friend."
DEREK: "There was a time that I thought you were the love of my life. Things change."

ADDISON: [interrupts Meredith and Derek kissing] "Well, isn't this cozy? Can I join in, or are you not in to threesomes?"
MEREDITH: "I have to go."

SAVANNAH: "I want my life. This gives me a shot, a shot at me and Weiss becoming this old wrinkled couple who argue all the time. Wouldn't you want that? A chance to grow old with Derek?"
ADDISON: [pauses] "Yeah. Yeah, I do."

[to Derek] "Medicine aside, our friends are going through hell in there, and we can't even act like we like each other long enough to help them."

[to Derek] "This whole thing brings back very traumatic memories of being a band geek, with braces and a lisp, spending the whole evening with Skippy Gold talking about Star Wars... So, do you want to dance?"

ADDISON: "I guess that puts an end to the evening."
DEREK: "Yeah."
RICHARD: "I guess it does." [Addison and Richard leave]
FINN: [to Meredith] "I'll drive you home."
DEREK: "Meredith." [Meredith, Finn and Derek all look at each other, exchanging knowing glances]
FINN: "Meredith..."

ADDISON: "Hey."
DEREK: "Hi."
ADDISON: "Where have you been?"
DEREK: "Oh, I was with..."

[the cast, narrating]
MEREDITH: "Human beings need a lot of things to feel alive."
GEORGE: "Family"
CRISTINA: "Love"
IZZIE: "Sex"
DEREK: "But we only need one thing"
RICHARD: "To actually be alive."
CRISTINA: "We need a beating heart."
ADDISON: "When our heart is threatened"
ALEX: "We respond in one of two ways."
GEORGE: "We either run or-"
IZZIE: "We attack."
RICHARD: "There's a scientific term for this."
ALEX: "Fight..."
ADDISON: "...or flight."
MIRANDA: "It's instinct."
MEREDITH: "We can't control it."
IZZIE: "Or can we?"

DEREK: "They just lost their daughter."
ADDISON: "I know. That's my point, Derek. They need to face that. She's not coming back."
DEREK: "A little sensitivity would be nice here, okay? They love their daughter. They don't want to let go. Alright?"

ADDISON: "I just have to ask... are you sleeping with my husband?"
MEREDITH: "Not since before I found out he was married."

ADDISON: "I know what you're going to say Richard, but if you knew the day I've had-"
RICHARD: "Everybody in this hospital has those days, Addison, and no one makes a scene in front of their peers. Get it together. [pauses] Addison?"
ADDISON: "I can't compete. He's not having an affair. He's not trying to hurt me. He's just... the only people who don't know that Derek loves Meredith are Derek and Meredith. How do I compete with that?"

DEREK: "What do you want from me, Addison?"
ADDISON: "I want you to care. I sleep with your best friend, and you walk away. Then he comes out here from New York and rubs it in your face, and you still get a good night's sleep. What do I have to do? Oh, I know. Maybe what I should do is go out on a date with the vet, because that seems to be something that sends you into a blinding rage. Oh, but wait. That won't work either because I'm not Meredith Grey."

Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey