Sheldon: This will just take a moment, it's on a five and a quarter inch floppy.
Amy: A floppy disk?
Sheldon: Well, I started the list when I was nine.

Penny: Wil Wheaton is Sheldon's mortal enemy.
Amy: Mortal enemy?
Penny: Mm-hmm.
Amy: Sheldon, I know you are a bit of a left-handed monkey wrench but... you really have a mortal enemy?
Sheldon: In fact, I have 61 of them.

Amy: If it makes you feel any better, the only person who signed my yearbook was my mother.
Leonard: Aww.
Amy: "Dear, Amy. Self-respect and a hymen are better than friends and fun. Love, Mom."

Amy: Should I go? I've been told, sometimes, I overstay my welcome.
Leonard: Wha ... who told you that?
Amy: Well, most recently my gynecologist.

Sheldon: Name your price.
Amy: Kiss me where I've never been kissed before.
Sheldon: You mean like Salt Lake City?
Amy: Nevermind.

You can't blame yourself. When your prefrontal cortex fails to make you happy promiscuity rewards you with the needed flood of dopamine. We, neurobiologists, refer to this as the skank reflex.

Amy: Have you considered massage?
Sheldon: I'd like to respond to that sarcastically: Yes, I relish the thought of a stranger covering my body with oil and rubbing it.
Amy: I was proposing you massage your muscles with your OWN hands.
Sheldon: (aback) Still sounds like a lot of unnecessary touching...

Amy: Although it is ... microbiology.
Sheldon: Your doctorate is in neurobiology. I fail to see the distinction.
Amy: I'll make it simple for you. I study the brain, the organ responsible for Beethoven's Fifth Symphony. Bernadette studies yeast, the organism responsible for Michelob Lite.

Commence operation "Priya Wouldn't Wanna Be-ya"

Amy: Good news: the wildebeest is in the curry.

The real danger is him biting off my face while I'm sleeping.

Amy: The meme has reached full penetration.
Sheldon: Pun intended?
Amy: No. Happy accident.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?