Sheldon: I can't give a speech.
Wolowitz: No, you're mistaken. You give speeches all the time. What you can't do is shut up.
Raj: Before the movie, you did twenty minutes on why guacamole turns brown. It turned brown while you were talking.

Raj: In Avatar, when they have sex on pandora they hook up their ponytails, so we know that their ponytails are like their junk.
Wolowitz: Yeah, so?
Raj: So when they ride horses and fly on the birds, they also use their ponytails...
Wolowitz: What's your point?
Raj: My point is if I were a horse or a bird, I'd be very nervous around James Cameron.

Wolowitz: How's it feel to get beaten up by a girl?
Sheldon: It's not the first time. I have a twin sister whose assaults began in utero. If only I'd had the presence of mind to absorb her. Then I'd have a mole with hair in it, instead of a tedious yearly Christmas letter.

Leonard: It should go back to Peter Jackson. He made the movies; it belongs to him.
Wolowitz: Fine, he can have it back -- as long as he promises to make me a hobbit in his next movie.
Raj: There are no Jewish hobbits.
Wolowitz: Clearly, you've never been to my house for dinner on Rosh Hashana.

Penny: Who's Adam West?
Sheldon: Who's Adam West!? Leonard, what do you talk about after the coitus?
Wolowitz: My guess is "four minutes, a new record!"

Wolowitz: Why do you have all of these unopened paychecks in your desk?
Sheldon: Because most of the things I'm planning to buy haven't been invented yet.

Wolowitz: Damn paper cut. Nothing worse than a paper cut!
Raj: Obviously you don't remember your circumcision.

I'd take Sheldon to Switzerland, absolutely. And I'd leave him there.

Wolowitz [about Sheldon]: How long's he been stuck?
Leonard: Intellectually about 30 hours, emotionally about 29 years.
Wolowitz: Have you tried rebooting him?
Leonard: No, I think it's a firmware problem.

I don't like to kiss and tell, but somebody made it to eighth base!

Wolowitz: I once dated a girl who believed she was abducted by aliens.
Leonard: And that didn't bother you?
Wolowitz: Au contraire; it meant she was gullible and open to a little probing.

Raj: Good news guys, I got the four hour special edition of Watchmen.
Leonard: Got it.
Wolowitz: Seen it.
Sheldon: Detailed analysis posted online.

TBBT Quotes

Sheldon [to Kripke]: Also, I am given to understand that your mother is overweight.
Raj: Oh, snap.
Sheldon: Now of course, if that is the result of a glandular condition and not sloth and gluttony then I withdraw that comment.

How is "doable" anything but a compliment?

Wolowitz