Penny: Yeah, I listen to what you say. You're building a particle detector using superfluid helium.
Leonard: You know, when you talk like that, I want to take you right here on this table.
Penny: And you know from past experience this table cannot support both our weight.

Penny: Sheldon, we are just people. we talk about the same things you guys talk about.
Sheldon: You talk about if werewolves can swim?

I love him, but if he's broken, let's not get a new one.

Sheldon: Nothing more fun than a paradigm shifting evening of science.
Penny: (to Leonard) And you thought it was soaping me up in the shower.

Leonard: Hang on. Why do we have to hate it?
Penny: Three words. Dr. Who Convention.

Penny: Oh, I know. We could go horseback riding.
Amy: Actually I can't. My hips don't open wider than 22 degrees. I rode a very thin pony once. On the first bump I just pssshh, popped right off.

Sheldon: You know, speaking of attorneys,if I ever needed a lawyer,I would not hire She-Hulk.
Penny: You know what? That was almost on topic. I'm gonna say, "Good job, Sheldon."

Bernadette: I mean, maybe I come off a little strong, but that's only because my dad raised me to be tough and not to take
crap from anybody.
Penny: No. That's fine, but there's a difference between being tough and telling your friend her new pants look like a saggy diaper.
Bernadette: I did say that, didn't I?
Penny: Yeah, you did. I felt so self-conscious, I had to return them.
Bernadette: Where? To Babies R Us?

Bernadette: What's his problem?
Penny: Oh. I don't know. Maybe he didn't like the fact that you called his grandson a wuss.
Bernadette: Well, I didn't think you were supposed to say "sissy" anymore.

Dan: Bernadette. Cute, sweet...vicious little Bernadette.
Penny: Come on. She's not that bad.
Dan: Oh, yeah? At the company picnic she yelled at me and my grandson for losing the three-legged race. I mean, he still calls her "that mean kid with the big boobies."

Penny: Okay, the reason he deceived you is you were being
a pain in the ass.
Sheldon: The reason I was being a pain in the B is because I was worried about him, and no one else was.
Penny: Really? You won't even say "A"?
Sheldon: You bet your sweet B I won't.

Sheldon: I assume this medical center's already treated the burns on your bottom from the recent pants fire.
Penny: 'Cause I'm a liar, liar?
Sheldon: That's for the fire marshal to determine.

TBBT Quotes

It's very simple. Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and, as it always has, rock crushes scissors

Sheldon

Sheldon: Why do you have the Chinese character for "soup" tattooed on your right buttock?
Penny: It's not "soup," it's "courage."
Sheldon: No it isn't. But I suppose it does take courage to demonstrate that kind of commitment to soup.
Penny: How'd you see it? You said you wouldn't look.
Sheldon: Sorry. As I told you, the hero always peeks.