PRESTON: "You aren't in the Christmas spirit."
CRISTINA: "I'm Jewish."
PRESTON: "Seriously?"
CRISTINA: [nods]
PRESTON: [pauses] "Oh. Well, if there are any traditions you want me to be aware of..."
CRISTINA: "Seriously, Burke, I haven't observed religious holidays since I was old enough to know better."

PRESTON: "I believe there's a mind/body/spirit connection. If Justin really doesn't want this heart, his body will reject it."
CRISTINA: "So, let me get this straight. You not only celebrate Christmas, but you actually believe in Santa Claus?"
PRESTON: [pauses] "Go clean up."
CRISTINA: "But we're not done here."
PRESTON: "You are."

PRESTON: "What do you want?"
CRISTINA: "What..."
PRESTON: "What do you want? You don't want to go out to dinner. You don't want to meet me in the on call room, and you sure as hell don't want to talk to me. I could pretend that I know, but hey, I don't even have your home phone number. So what do you want!?"

PRESTON: "So what's the story with you and Grey?"
DEREK: [pauses] "I got drunk and she took advantage of me. Or she got drunk and I took advantage of her. Well, either way, we were drunk, definitely, and somebody took advantage. I look at it as my initiation into Seattle. What about you?"
PRESTON: "I don't have a story, I just wanted to hear yours."

CRISTINA: "What's wrong?"
PRESTON: "Oh, nothing. Just dragging a little. I only did two miles this morning. O'Malley and I were up to six, we pushed each other."
CRISTINA: "Ah, you're missing George."
PRESTON: "No. No, of course not."
CRISTINA: "Drink your coffee."

PRESTON: [to George] "You want in on Foote?"
GEORGE: "Yes, but I'm on neuro today with Dr. Shepherd." [runs off]
CRISTINA: "Uh, hello? I want in. I want in!
PRESTON: [pauses] "Oh. Yeah. Sure."
CRISTINA: "Burke, I laid on top of you naked last night, so why don't you wax nostalgic about that?"

CRISTINA: "He wants you to take it out?"
PRESTON: "Yes... he says he can't play with it."
CRISTINA: "He can't play anymore?"
PRESTON: "He can... but not like Eugene Foote."

PRESTON: "I wasn't like you. I wasn't the most talented student in school. I wasn't the brightest. But I was the best."
CRISTINA: "You practiced."
PRESTON: "I practiced."

BURKE: "I need… you to… to go check on Denny Duquette."
CRISTINA: "Okay... That was my best supportive girlfriend and you kinda ruined it with medicine. But it's okay."

MIRANDA: "Anything I can get for you, Dr. Burke?"
PRESTON: "No, I'm fine."
MIRANDA: "There, there must be something."
PRESTON: "It would be nice to have some ice chips. And, uh... a touch of morphine, if I'm allowed. And... Cristina."
MIRANDA: "Coming right up. [pauses] Where is Cristina? Where are... where are all the little suck-ups?"
PRESTON: "Excuse me?"
MIRANDA: "My interns. My ass-kissing, surgery-hungry, competitive suck-ups. Where are they? Why aren’t they here fetching you ice chips and morphine? You know something."
PRESTON: "I'm a patient."
MIRANDA: "Preston Xavier Burke, what have you done with my suck-ups?"

[the cast, narrating]
MEREDITH: "Human beings need a lot of things to feel alive."
GEORGE: "Family"
CRISTINA: "Love"
IZZIE: "Sex"
DEREK: "But we only need one thing"
RICHARD: "To actually be alive."
CRISTINA: "We need a beating heart."
ADDISON: "When our heart is threatened"
ALEX: "We respond in one of two ways."
GEORGE: "We either run or-"
IZZIE: "We attack."
RICHARD: "There's a scientific term for this."
ALEX: "Fight..."
ADDISON: "...or flight."
MIRANDA: "It's instinct."
MEREDITH: "We can't control it."
IZZIE: "Or can we?"

PRESTON: "You're a good person."
CRISTINA: "No, I'm not."
PRESTON: "You're helping a friend."
CRISTINA: "Are his problems surgical?"
PRESTON: "No."
CRISTINA: "Then we can't help him."

Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey