Sam: No wonder none of the tests worked. You're not shapeshifers. You're ghouls.
Kate: You know, I find that term racist.

Dean: Adam doesn't have to be cursed.
Sam: He's a Winchester. He's already cursed.

Dean: I'm starving, lets get breakfast.
Sam: Where? We're like two hours from anything.
Dean: But I'm hungry now.
Sam: There is probably still a sandwich in the backseat.
Dean: It's tuna.

Dean: It frustrates me when you say such reckless things.
Sam: Well, it frustrates me when you'd rather hide than fight.

Sam: Get out of me.
Dean: You're such a prude. Come on.

Sam: Wow, it's like a magic museum.
Dean: You must be in heaven.

Dean: What a douchebag.
Sam: That's Jeb Dexter.
Dean: I don't even want to know how you know that.
Sam: He's famous, kind of.
Dean: For what, douchebaggery?

Dean: I can't believe people actually fall for that crap.
Sam: It's not all crap.
Dean: What part of that was not a steaming pile of B.S.?

Sam: What are you doing here, Ruby?
Ruby: I should be asking you the same thing.
Sam: I'm working a job.
Ruby: The whole world's about to be engulfed in hellfire, and you're here in Magictown, U.S.A.
Sam: You got something against magic?

Sam: It's probably a dumbwaiter. All these old houses had them.
Dean: Know-it-all.
Sam: What?
Dean: What?
Sam: You said...
Dean: What?
Sam: Never mind.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean