I'm in love with this incredible guy and we're having problems....
Izzie: I'm in love with this incredible guy and we're having problems. And my best friend, he would know what to say to me about it. I need to be able to talk to my best friend. I cannot get through this without my best friend.
George: Why isn't this easier?
Izzie: I don't know.
George: Well, I want my best friend back.
Izzie: Me too.