James: What would Sam want you to do?
Lena: Sam wanted me to heal her.
James: Not what Sam wanted you to do. What would Sam want you do now, with the choice you are presented with?
Lena: She would choose Ruby. Over anything. Even her own life. She'd want me to protect her daughter.

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Supergirl Season 3 Episode 20: "Dark Side of the Moon"
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Supergirl Season 3 Episode 20 Quotes

Winn: You seem more stoic and grave than usual, which if we're being honest is making me a little bit queasy. What haven't you told me?
J'onn: Reign is becoming immune to Miss Luthor's synthetic Kyrptonite faster than we expected.

Supergirl and I may not see eye to eye, but there is one thing we can agree on, and that's that you need to be stopped. So enjoy your moment in the sun, Reign, because we are going to save Sam, and end you.