CRISTINA: "We're in an elevator. That's your specialty, right? McDreamy moments in the elevator?"
DEREK: "Dr. Yang-"
CRISTINA: "You know what? For just a moment, I’m not Dr. Yang and you’re not Dr. Shepherd. You’re the guy who screwed up my friend. The guy who drove her to get a dog she can't keep, the dog she only got because her boyfriend lied to her about his wife."
DEREK: "I never lied to her."
CRISTINA: "Yes you are. You know, I know a liar when I see one because I am a liar."

• Permalink: We're in an elevator. That's your specialty, right? McDreamy mo...
• Added: March 05, 2006

GEORGE: "What happened today?"
IZZIE: "Nothing."
MEREDITH: "Nothing."
GEORGE: "Okay then."
IZZIE: "We don’t know everything about each other, George."
MEREDITH: "Yeah."
GEORGE: [pause] "True. Anybody wanna have sex?"

• Permalink: What happened today? Nothing. Nothing. Okay then. We do...
• Added: March 05, 2006

IZZIE: "I just... I just need some sex, George. You know, I just, I need sex NOW. You know what I mean?"
GEORGE: "No matter how hard you beg, I am not doing you."

• Permalink: I just... I just need some sex, George. You know, I just, I nee...
• Added: March 04, 2006

"I guess we can't really complain about karma. It's not unfair. It's not unexpected. It just evens the score."

GEORGE

• Permalink: I guess we can't really complain about karma. It's not unfair....
• Added: February 27, 2006

[to Addison] "I'm too tired to interpret crazy girl talk into anything coherent right now."

DEREK

• Permalink: I'm too tired to interpret crazy girl talk into anything coher...
• Added: February 27, 2006

MEREDITH: "I did a terrible thing."
DEREK: "We all do terrible things."
MEREDITH: "No... I... I really think that I have just lost all my friends."
DEREK: "You won't lose me."
MEREDITH: "You aren't my friend."
DEREK: "Sure I am."

• Permalink: I did a terrible thing. We all do terrible things. No... I....
• Added: February 27, 2006

"George, if you're sick of bad things happening to you, stop putting up with it and demand better."

CRISTINA

• Permalink: George, if you're sick of bad things happening to you, stop put...
• Added: February 27, 2006

PRESTON: "You're a good person."
CRISTINA: "No, I'm not."
PRESTON: "You're helping a friend."
CRISTINA: "Are his problems surgical?"
PRESTON: "No."
CRISTINA: "Then we can't help him."

• Permalink: You're a good person. No, I'm not. You're helping a friend....
• Added: February 27, 2006

[to Meredith] "That's what you do. When you feel sorry for yourself, you get drunk and sleep with inappropriate men. It's okay. I find it charming."

ALEX

• Permalink: That's what you do. When you feel sorry for yourself, you get ...
• Added: February 27, 2006

[Referring to Meredith] "I saw her first!"

GEORGE

• Permalink: I saw her first!
• Added: February 22, 2006

ALEX: "Why are you helping me after what I did?"
IZZIE: "'Cause it's what Jesus would freaking do!"

• Permalink: Why are you helping me after what I did? 'Cause it's what Jes...
• Added: February 22, 2006

[to Addison] "There is a land called Passive Agresseva, and you are their queen."

DEREK

• Permalink: There is a land called Passive Agresseva, and you are their qu...
• Added: February 22, 2006