[narrating] There comes a point in your life, when you’re officially an adult. Suddenly, you’re old enough to vote, drink and engage in other adult activities. Suddenly, people expect you to be responsible, serious, a grown-up. We get taller, we get older. But do we ever really grow up?

Meredith

Meredith: What's new with you?
Derek: I had dinner and a movie... with the Chief!

Mark: [about Erica] She's sassy!
Derek: She's a woman of substance. You two have nothing in common.

Kid: But I still get something right? You said that after We get to the hospital I would get whatever I wanted!
Mother: Absolutely sweaty, you were really brave.
Father: Yeah, what do you want?
Kid: I want you guys to get a divorce!

[narrating] Chemistry. Either you've got it, or you don't.

Meredith

I am painting Burke's apartment so I can stop calling it Burke's apartment. A happy color. Red. Like blood.

Christina

I love George. Oh, God I do, I love him, and I'm so happy because he's kind and smart and um, sweet and sexy. He's perfect, perfect, except for the fact that he kisses like a chicken. You know a chicken pecking the ground for food, justs pecking and pecking and pecking, and when he's pecking at me like that I forget that I love him, I forget that he's kind and sweet and sexy and I just wanna scream, "Stop pecking at me!" Did he peck you like a chicken, Mer?

Izzie

George: It's horrible. The sex. With Izzie... horrible. It's like she's trying to hard, it... it's...you ever seen a porno? Not that Izzie's a porno; she's an angel, but it's like she's trying to... channel a porn star and she's trying to act all dirty and sexy, which sounds great, right? But in reality I just wanna say, "Izzie, just because you can do that with your legs doesn't mean that you should."
Meredith: Eh... I wanna run.
George: Run, run. Run now!

George: Hey.
Meredith: You look weird.
George: I don't look weird.
Meredith: What's wrong?
George: I look fine.
Meredith: I know you.

Derek: Oh, I'm late. Dropped off the Chief's dry cleaning.
Mark: You're doing his laundry?
Derek: I'm helping out.
Mark: Yeah, what's he doing?
Derek: He has an extensive DVD collection.
Mark: [pauses] You're dating the Chief. Huh!

Meredith: [narrating] Before we were doctors, we were med students, which meant we spend a lot of time of studying chemistry. Organic chemistry, biochemistry, we learned it all. But when you're talking about human chemistry only one thing matters: either you've got it or you don't.

Derek: What's new with you?
Meredith: I saw my half-sister half naked.

Grey's Anatomy Season 4 Quotes

I tell you that I love you, and not one word? For 17 days? Where have you been?

Izzie

[narrating] In the practice of medicine, change is inevitable. New surgical techniques are created, procedures are updated, levels of expertise increase. Innovation is everything, nothing remains the same for long. We either adapt to change, or ... we get left behind.

Meredith