We protected the humans of this city by killing a monster. Not even Supergirl could do that.

George

James: But I also know you, and I know you're better than this.
Lena: I will not allow you to judge me and my use of science for the betterment of humanity.

Actually, Alex doesn't know I'm Supergirl anymore. She had her mind wiped to protect her. But I can't let that stop me from helping the people that need my help. And doing the good that I can do. And you could do a lot of good too. You're part of my family now. And all heroes are welcome.

Kara (to Nia)

Brainy: It never occurred to me that someone as amazing as Nia Nal would ever be interested in me.
Alex: Well, I guess the question is, what do you want?
Brainy: I want her to be my Valentine.

Brainy: Have you ever thought about putting your grief into tiny little boxes?
Nia: That doesn't sound very healthy.

Supergirl Season 4 Episode 12 Quotes

Brainy: It never occurred to me that someone as amazing as Nia Nal would ever be interested in me.
Alex: Well, I guess the question is, what do you want?
Brainy: I want her to be my Valentine.

Brainy: Have you ever thought about putting your grief into tiny little boxes?
Nia: That doesn't sound very healthy.