Castiel: The only thing you're going to see out there is Michael killing your brother.
Dean: Well, then I ain't gonna let him die alone.

Sam: Were you racing me?
Dean: No, I was kicking your ass.
Sam: Very mature.

Just because you're blood doesn't mean you're family. You have to earn it.

Dean

Welcome to next time.

Dean

I mean at the end of the day, you two are family. Life's short. Ours are shorter than most. Are we gonna spend it wringing our hands? Something's gonna get us. Eventually. And when my guts get ripped out, just so you two know, we're good. Blanket apology for all the crap that anybody's every done. All the way around.

Dean

Dean: Well, hey there, you little herpe.
Sam: Why do you keep talking about herpes?
Dean: What? I don't. Shut up. Shut up.

Rufus: We're here. Let's do this. Just like old times.
Bobby: Well, as long as I get to drive.
Rufus: Hell, no.

Rufus: I take it you know each other.
Dean: He's our grandfather.
Rufus: Somebody needs a hug.

Sam: So, now ah, what's the deal with all this TV crap?
Castiel: Pardon me?
Dean: Yeah, amen Padaleski.
Sam: Padalecki.,
Dean: What?
Sam: -Lecki, I'm pretty sure.

Dean: Seriously. Why? Why would anybody want to watch our lives?
Sam: Well, according to the interviewer, not very many people do.

What kind of douchebag names a character after himself?

Dean

It appears that Jared and Jensen were seen beating an extra to death.

Bob Singer

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean