Sam: You totally Butterfly Effected history.
Dean: Dude. Dude. Rule 1: No Kutcher references.

Sam: So you save the cruise liner because...
Balthazar: Because that god-awful Celine Dion song made me want to smite myself.

Balthazar: I hated the movie.
Dean: What movie?
Balthazar: Exactly.

Accidents don't just happen accidentally. You know what I mean.

Dean

You two gonna stand there like the ugly girl at the prom or are you going to pitch in?

Bobby

Sam: Were you racing me?
Dean: No, I was kicking your ass.
Sam: Very mature.

Just because you're blood doesn't mean you're family. You have to earn it.

Dean

Welcome to next time.

Dean

I mean at the end of the day, you two are family. Life's short. Ours are shorter than most. Are we gonna spend it wringing our hands? Something's gonna get us. Eventually. And when my guts get ripped out, just so you two know, we're good. Blanket apology for all the crap that anybody's every done. All the way around.

Dean

Dean: Well, hey there, you little herpe.
Sam: Why do you keep talking about herpes?
Dean: What? I don't. Shut up. Shut up.

Rufus: We're here. Let's do this. Just like old times.
Bobby: Well, as long as I get to drive.
Rufus: Hell, no.

Rufus: I take it you know each other.
Dean: He's our grandfather.
Rufus: Somebody needs a hug.

Supernatural Season 6 Quotes

How do you keep your lawn so green? C'mon Dean, you've never been what I call, Brady.

Yellow-Eyed Demon

It's like chicks specifically dig unavailable guys.

Dean