Sheldon: She stiffed you?
Penny: I believe that's what he did to her.

I'm so proud of you! You sold yourself out like a common streetwalker!

Sheldon

Good morning, slut.

Penny

Given how much time you spend engaging in pointless self-abuse, you might consider just this once using your genitalia to actually accomplish something.

Sheldon

It is to viagra as viagra is to a green M&M.

Sheldon

Penny, you're an expert on trading sexual favors for material gain, walk him through this.

Sheldon

You seem to have forgotten the reason we live together is that we're best friends. And I've got your back, Jack.

Sheldon

An entire dinner to talk about your research? Where you goin, the drive thru at Jack In The Box

Sheldon

Amy: This year's donations may go to, say, the geology department.
Sheldon: Oh dear, not the dirt people.

Until you manage to upload your intelligence into a self-sustaining, orbiting satellite equipped with high-speed internet and a cloaking device, you will be dependent on the human race.

Amy

Your critical attitude is ruining our Saturday night together, and I'm not above minimizing your window.

Sheldon

What happened to you Wolowitz? Couldn't stick with it long enough to get your PhD?

Mrs. Latham

The Big Bang Theory Season 4 Episode 15 Quotes

It's not a touch phobia, it's a germ phobia. If you'd like to put on a pair of latex gloves I'll let you check me for a hernia.

Sheldon

You take this one. I spent an hour last night on 'Why can't vampires shave when they can't see themselves in the mirror?'

Howard