Raj: Missy, do you enjoy pajamas?
Missy: I guess.
Raj: We Indians invented them. You're welcome.
Wolowitz: Yeah, well, my people invented circumcision

Wolowitz: Okay, you two have to back off.
Raj: Why should I back off? You back off, dude.
Leonard: Excuse me, this is my apartment, and she's my roommate's sister.
Howard: So what? You've already got Penny.
Leonard: How do I have Penny? In what universe do I have Penny?
Wolowitz: So, I can have Penny?
Leonard: Hell, no!

I'd kill my rabbi with a pork chop to be with your sister

Wolowitz

Missy: Shelly, can I speak to you a minute—alone?
Sheldon: Why does everyone suddenly want to talk to me alone? Usually no one wants to be alone with me

Sheldon: You see, I'm a superior genetic mutation, an improvement on the existing mediocre stock.
Missy: And what do you mean, "mediocre stock?"
Sheldon: That would be you

Leonard: So, how do you two know each other?
Missy: He once spent nine months with my legs wrapped around his head.
Leonard: Excuse me?
Sheldon: She's my twin sister. She thinks she's funny, but frankly, I've never been able to see it.
Missy: That's because you have no measurable sense of humor, Shelly.
Sheldon: How exactly would one measure a sense of humor? A "humormometer?"

The Big Bang Theory Season 1 Episode 15 Quotes

Sheldon: You see, I'm a superior genetic mutation, an improvement on the existing mediocre stock.
Missy: And what do you mean, "mediocre stock?"
Sheldon: That would be you

Leonard: So, how do you two know each other?
Missy: He once spent nine months with my legs wrapped around his head.
Leonard: Excuse me?
Sheldon: She's my twin sister. She thinks she's funny, but frankly, I've never been able to see it.
Missy: That's because you have no measurable sense of humor, Shelly.
Sheldon: How exactly would one measure a sense of humor? A "humormometer?"