Daisy becomes Hive's walking blood bag in his quest to turn humans to Inhumans. Her blood donation leaves her weak and vulnerable, which makes the S.H.I.E.L.D. team question whether Hive is concerned with keeping their friend around anymore. If she can make 100 Inhumans, why not lose her?
Hive's trials don't work even with Daisy's blood. The Watchdog members that he captured to turn into Inhumans turned into abominations. Deformed people that hardly look like people anymore, but that's fine with Hive. They have super strength, superpowers, and are perfect enough for Hive to get what he wants.
Daisy's repeated hacking into S.H.I.E.L.D.'s system leaves Fitz scrambling to keep her out, though Daisy is the one who created the system, so it's a wasted effort. Lincoln appeals to her and convinces her to help break him out, a valiant and successful mission. A fake out mission.
Instead of Lincoln flying out of the base, it's Lash, a plan that May and Lincoln set up together. Who better to take down an Inhuman than an Inhuman that lives to destroy all Inhumans?
Talbot returns to confront Coulson about the Sokovia Accords introduced in Captain America: Civil War, and Coulson has a surprising reaction.