When Talbot is named as the new head of the ATCU, Coulson must team up with him to clean up the inhuman mess that is plaguing the world. Talbot, still afraid of aliens, is on a very different page and cannot seem to figure out his own agenda as he loses his wife over this new career decision. 

Daisy struggles with her new relationship with Lincoln and the projection that the world has placed to represent her and the Inhumans. As some people want them cured, some want to use them, and some want to prevent the process from ever repeating. Daisy still maintains that they are not a disease, they do not need to be cured, but Lincoln feels differently.

Bobbi, May and Hunter are tasked with protecting the Director and Talbot as they attend a worldwide symposium about the alie infestation of their planet, where they search for an inside man: Hydra's connection to the world council. Little does S.H.I.E.L.D. know that Talbot is the traitor, but only through blackmail: Malick kidnapped his son. Meanwhile, Hunter is distracted by Creel's status as Talbot's bodyguard, still upset over Hartley and Idaho's deaths.

Jemma and Fitz continue their new, fresh relationship, content with rediscovering who they are with each other, taking it slowly as the situation becomes more dire in the SHIELD vs. Hydra battle.

At Hydra headquarters, Hive reveals that they're planning something big, but only as he plans to devour humans to revive Ward's body to serve as an adequate host.