-Tess Walters, human rights work in Cuba is kidnapped and thrown in a Cuban prison. The Angels are hired to break her out.
-The Angels enter Cuba as American tourist and get themselves arrested for carrying drugs. They find Tess and are pulled into a prostitution ring run out of the prison by a corrupt guard and international businessman Jonathan Cartwright.
-The Angels escape with the girls but Eve is left behind as a hostage.
-Bosley runs into former flame and current CIA operative Samantha Masters who helps them rescue the girls. She also mentions a woman from Bosley's past named Elizabeth, who he couldn't save.
-Cartwright wants Samantha in exchange for Eve. Bosley persuades the corrupt prison guard to help them capture Cartwright but then has the guard thrown in her own prison.
-Samantha stays in Cuba to continue to dismantle Cartwright's operation.
-Back home, Bosley and Charlie privately discuss their sorrow over Elizabeth's death. She was Charlie's daughter.