"I Saw What I Saw"

A burn victim's death in a chaotic ER prompts the Chief and the board to find who is responsible, as all the Mercy West and Seattle Grace residents scramble to save their jobs.

"Invasion"

Newly-merged Seattle Grace and Mercy West residents vie for surgeries and their careers, while Arizona stands by Callie when her father employs a priest to convince her to date men, and Izzie experiences the brunt of her new competition.

"Tainted Obligation"

When Meredith and Lexie Grey's father, Thatcher, returns to the hospital with a failed liver, it's up to Meredith to save his life. That won't be easy for myriad reasons.

"I Always Feel Like Somebody's Watchin' Me"

Izzie returns to work after a near-death experience. An announcement from the Chief has residents expecting layoffs and scrambling to survive the cuts.

"Goodbye"

The doctors of Seattle Grace continue to battle their own demons and cope with the loss of George in their own way, while a couple of patients make a big impact on the doctors, too.

"Good Mourning"

The Season 6 premiere of Grey's Anatomy kicks off on a somber note as Dr. George O'Malley is laid to rest and the Seattle Grace doctors are profoundly impacted in their own ways.

"Now or Never"

The fifth season concludes with George making a stunning announcement, Bailey questioning her pediatric fellowship program, and Izzie's fate hanging in the balance.

"Here's to the Future"

The first of a two-part season finale finds Izzie fighting for her life as Mark and Owen contemplate their future relationships and careers.

"What a Difference a Day Makes"

As Grey's Anatomy turns 100, Meredith and Derek prepare to walk down the aisle as Izzie's condition brings back familiar (handsome!) symptoms.

"No Good at Saying Sorry (One More Chance)"

As preparations continue for Meredith and Derek's wedding, her father returns to make amends. Izzie receives a visit from one of her estranged parents, as well.

Grey's Anatomy Quotes

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)