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Now that Bailey is aware of Meredith and Sheppard's procedural relationship outside the hospital, things are a bit tense. While Bailey won't give this duo up, she will make life difficult if Meredith is afforded any special treatment. As a result, Sheppard is extra harsh to Meredith in public.

Alex, conversely, is being unusually kind to a woman named Annie with a 70-pound tumor. He's about to scrub in for surgery with Dr. Burke until the patient overhears Alex making disparaging remarks about her during an MRI. Subsequently, Cristina and George are left with the supposed honor of holding up the tumor during surgery. Alex and Izzie are therefore left on rounds, but the former leaves Izzie alone as he laments the decision to keep him away from the procedure.

Annie ends up dying on the table and Alex seems to regret his attitude toward her. Meredith is also sorrowful for thinking badly of how Sheppard treated her. He ends up supporting his favorite intern/lover after she convinces a patient with Parkinson's Disease to seek a certain treatment in order to make it down the aisle for his daughter's wedding.

After Annie dies, Cristina is left in physical and emotional pain. Burke finds her and an initial awkwardness is soon replaced with another sexual romp.

Grey's Anatomy
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Grey's Anatomy Season 1 Episode 6 Quotes

[narrating] "The early bird catches the worm; a stitch in time saves nine. He who hesitates is lost. We can't pretend we haven't been told. We've all heard the proverbs, heard the philosophers, heard our grandparents warning us about wasted time, heard the damn poets urging us to ‘seize the day'. Still sometimes we have to see for ourselves. We have to make our own mistakes. We have to learn our own lessons. We have to sweep today's possibility under tomorrow's rug until we can't anymore, until we finally understand for ourselves like Benjamin Franklin meant. That knowing is better than wondering, that waking is better than sleeping. And that even the biggest failure, even the worst most intractable mistake beats the hell out of never trying."


GEORGE: [bringing Meredith coffee] "Ahh! Hot!"
IZZIE: "Wouldn't it be easier to just ask her out?"