Vanessa becomes possessed again, this time to dangerous results. Sir Malcolm, Ethan, Victor and Sambene work together to try and keep her safe, but the devil makes his way into her again and again. He even comes in the form of Ethan and tries to seduce her with promises of her being by his side when he takes over the world.
Meanwhile, Ethan and Victor bond as Ethan shows the young doctor how to fire a gun. Victor sees Caliban standing outside of Sir Malcolm's house, still wanting his bride, but he never goes out to meet him.
In the end, Vanessa nearly kills herself, the men protecting her and even a priest trying to deliver Last Rites. In a short moment of clarity, she begs Ethan to kill her and end her misery but instead he begins chanting in Latin and performs an exorcism. Vanessa survives the ritual and when she awakes, she announces to Sir Malcolm that she knows where Mina is.