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Violet comes home and to the practice. Amelia butts into Sam's personal life. Sheldon encourages Charlotte to reconcile with Cooper.
Famed neurosurgeon Dr. Ginsberg pays a visit to St. Ambrose. Addison is shocked to see Amelia Shepherd - Derek's younger sister on the team.
A patient wants to pull the plug on his comatose wife. Several relationships are on the verge of the plug being pulled as well.
Addison's patient and the life of the three unborn babies hang in the balance. Sam's new girlfriend and Addison are divided on the treatment. Cooper seeks Sheldon's help with a young patient. Naomi has a dilemma with between William and Dr. Fife.
Addison, Pete and Sam work on a case involving a dad-to-be who comes down with tuberculosis and threatens the future of his new family. Naomi finds herself in a love triangle.
Violet helps Sam with Maya's wedding. Naomi refuses to take part. Addison and Pete try to save a premature baby. Cooper suspects Charlotte's new boyfriend of abusing pills.
Sam convinces Violet to help plan Maya's wedding. Tension between Addison and Sam rise. Cooper and Pete treat a teen with a mysterious bite mark on her neck.
Addison and Cooper counsel a couple who must make an unthinkable choice. Sam is dealt another blow when he finds out Dink's intent to marry Maya.
Sam and Naomi are stunned by Maya's announcement. Pete challenges Fife on a patient with a cutting edge bionic arm.
Part II of a Grey's Anatomy-Private Practice crossover event. Mark follows Addison back to California in an effort to pursue treatment for his daughter.