A therapist dies after a bad mushroom-induced trip and she and Charlie talk. She gets Charlie to admit that the reason he isn't awake is because he doesn't want to wake up.

After Joel bails out of a surgery, Kinney takes him to her hometown to help teach a continuing education class. While there they must amputate the leg of one of Dana's life-long friends after a tow truck crashes into the woman. The two later have a romantic rendezvous in a hotel room.

Alex treats a male patient who, after losing 120 pounds, is diagnosed with breast cancer.