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Sheldon is fired from his job at Caltech when he insults his boss Dr. Eric Gablehauser (Mark Harelik).  Unemployed, Sheldon quickly spirals into depressions which Leonard tries to end by bringing over Sheldon's mother (Laurie Metcalf).

When his mother arrives, she turns out to be the complete opposite of Sheldon, a sweet, devout Christian woman.  Sheldon's mom forces him to apologize and he gets his job back.  His mom also flirts with Dr. Gablehauser and Sheldon asks if he's going to be his new Daddy.  His mom says "we'll see."

The Big Bang Theory
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The Big Bang Theory Season 1 Episode 4 Quotes

Wolowitz: Forgive me for being so bold, but I now see where Sheldon gets his smoldering good looks.
Mary: Honey, that ain't gonna work, but you keep trying.

Sheldon: I can't believe he fired me.
Leonard: Well, you did call him a "glorified high school science teacher whose last successful experiment was lighting his own farts."
Sheldon: In my defense, I prefaced that with, "with all due respect."