It’s Easter, but Alexander continues to fast. A new taster is recruited, and Antonello gets the job – Della Rovere’s assassin is ready to strike. In Florence, Cesare challenges Savonarola to a trial by fire. Raffaello meanwhile, formally asks for Lucrezia’s hand but Alexander sends the brothers packing.

Giulia persuades Alexander that his Papacy has been a good thing, so he ends his fast and orders a celebration for the baptism of Lucrezia’s baby. At the party, Antonello is ready to strike but is thwarted by Alexander’s switch from water back to wine. As the party continues, Juan is completely out of control, and threatens the life of Lucrezia’s child. A chilling Cesare at last comes to terms with what needs to be done.