No one is safe on Grey's Anatomy, and we mean no one. Here are 10 main cast members who have left the show.
Burke and Cristina were just about to be married, but instead, Burke left Cristina at the alter at the end of Season 3. He returned in Season 10 briefly, offering Cristina a job in Zurich.
Addison also left in Season 3, heading to Calfornia. She didn't leave us entirely, though, since we were able to enjoy her character more fully on the spin-off, Private Practice.
The first doctor to be killed off and cause us to cry ugly tears, George was hit by a bus while trying to save another person. His friends all tried to save him, not realizing who he was until he finally was able to communicate his identify by tracing the numbers "007" on Meredith's hand.
Izzie overcame cancer and was even re-hired after being fired from the hospital, only to decide to leave Alex and everything else behind.
Erica Hahn just sort of disappeared, last seen heading to her car never to return to the hospital.
Causing even more ugly crying, Lexie Grey was a victim of the plane crash in Season 8. It was completely devestating.