Lily Anderson was brought to the hospital on Grey's Anatomy Season 8 Episode 10 after her family crashed into the back of the ambulance during a rainstorm carrying Meredith, Alex, and a premie baby. She chose to take her father off ventilation declaring that she was the head of the household after having turned 18 four hours prior. Watching both her parents and her grandmother die and realizing she was now in charge of her two younger siblings was heartbreaking to watch. What a tragic story.
Wallace Anderson was the little boy from Grey's Anatomy Season 6 Episode 8 who suffered from Short Gut Syndrome. His parents decided to donate $25 million dollars to the hospital for research to find a cure for Wallace's condition. His health quickly went downhill and his parents pressured Arizona Robbins into performing a risky surgery in order to extend his life by two months. He died due to septic shock after the procedure.
Cece Colvin was the matchmaker from Grey's Anatomy Season 15 Episode 24 who had a rocky hospitalization. She helped Meredith find love again before her sad death during her kidney transplant. She was such a light at the hospital with her belief in love and happiness. It was a hard death for the season.
Frankie was a patient who died while waiting for a heart transplant on Grey's Anatomy Season 10 Episode 21. Christina Yang made the hard decision to give the available heart to Frankie's sister Ivy who had a greater chance of survival. They attempted to give Frankie an artificial heart, but she died in the OR. Frankie's parents had gone through the wringer watching all three children simultaneously fight for their lives. It was truly heartwrenching witnessing Owen and Christina break the news to her parents. When Christina cries it's serious.
Beatrice Carver was the mother of a daughter who hid the fact that she was dying of cancer on Grey's Anatomy Season 2 Episode 22. It wasn't until the end of the episode when she sits her daughter down and imparts all her motherly wisdom onto her that she finally reveals she won't be getting any better. This mother-daughter moment had us all in tears as we went to go hug or call all of our mothers.
Denny Duquette, does he even need a description? Izzy Steven's eventual fiance who came in for a heart transplant, but after many complications decided to get an LVAD on Grey's Anatomy Season 5 Episode 23. Once they found a heart for him they needed to prove he was in bad enough shape to need it, so Izzie cut his LVAD to worsen his condition. He received the heart, but threw a clot and died as Izzie was running to him to show her wedding dress.
Wait! There's more Saddest Grey's Anatomy Cases of All Time! Just click "Next" below: