The Big Bang Theory
Before it was The Big Bang Theory, the CBS comedy was Lenny, Penny, and Kenny. (Sheldon was originally supposed to be named Kenny.) It's a good thing that chance was made, because The Big Bang Theory sounds better. It's hard to imagine a show called Lenny, Penny, and Kenny, would have lasted as long.
A working title for the TGIT favorite Scandal, was actually Damage Control. That's not so bad, but it doesn't feel quite the same, does it?
Let's be honest. Nowhere would have been a perfectly appropriate title for Lost, and it was nearly the one that was chosen. Still, Lost is much better.
It's Always Sunny in Philadelphia
Fitting? Sure. But It's Always Sunny in Philadelphia feels like the better choice over the show's working title, Jerks.
Just imagine if Miley Cyrus had become known for her role on Alexis Texas -- because this is a thing that almost happened. Let's all be glad the show was changed to Hannah Montana instead.
Before it was Seinfeld, the hit comedy had a bit of a clunkier title with a more serious tone: The Seinfeld Chronicles.