George and Lemon - Hart of Dixie
We might have found George and Lemon adorable, but George's mom had a different opinion. She found Lemon silly and high strung and was increasingly horrible to her.
Harvey and Sabrina - Chilling Adventures of Sabrina
Sabrina's parents weren't as big of an issue as much as her coven was. Sabrina is a witch while Harvey is not, and her coven didn't approve of her dating a mortal
Michael and Alex - Roswell, New Mexico
One thing to know about Roswell, New Mexico, is that Alex's father is the worst character. He was abusive and unaccepting of his son's sexuality. When he caught Michael and Alex together he tried to attack Alex, but Michael jumped in between them. He broke Michael's hand, which was scarred for a decade.
Emily and Daniel - Revenge
Daniel's mother, Victoria, despised Emily and we do kind of understand it. After all, Emily was actually Amanda Clarke and she had been playing Daniel for quite some time.
Samantha and Darrin - Bewitched
Samantha's mom, Endora, hated that Samantha married a mortal. She never called him by his correct name to illustrate her dissatisfaction and it was a running gag throughout Bewitched.
Magnus and Alec - Shadowhunters
It's hard to believe how against this relationship Maryse Lightwood was at the beginning of Shadowhunters. But she's grown significantly since the start of the show and is now the number one Malec stan.