Rhimes says we'll see Alex "being more of a man" now that he's living with Jo. The doctor will also feel a "responsibility for Meredith," which we love to hear and see.

Look for Miranda to make a play to be chief of surgery on the premiere, while Rhimes says we'll "watch her struggle with growing up in that sense."

Richard is now married to Catherine... his boss. And this "balance of power is harder for an old-fashioned guy like him to deal with," previews Rhimes.

Rhimes intriguingly teases: "Owen's goin to find himself moving in with somebody that he had not planned to."

Is Jackson "going to be a guy who stays or is he doing to be a guy who goes?" Rhimes asks of whether Jackson can take April back.