Grey's Anatomy Season Premiere Spoiler Photos: So. Many. Changes.

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What's next?

Grey's Anatomy Season 19 Episode 1 sends the long-running medical series in a very different direction.

The series will shift focus to a new group of interns when it premieres Thursday, October 6 on ABC.

Scroll down to see all the photos from the premiere.

Remember, you can watch Grey's Anatomy online right here via TV Fanatic.

1. Back Together - Grey's Anatomy Season 19 Episode 1

Back Together - Grey's Anatomy Season 19 Episode 1
Everyone is back and ready to make some big changes on Grey's Anatomy Season 19 Episode 1.

2. Watching History? - Grey's Anatomy Season 19 Episode 1

Watching History? - Grey's Anatomy Season 19 Episode 1
The hospital is getting back to its roots and teaching the interns. How long will that work out?

3. Maggie is Back - Grey's Anatomy Season 19 Episode 1

Maggie is Back - Grey's Anatomy Season 19 Episode 1
Maggie is helping out in one of the surgeries on Grey's Anatomy Season 19 Episode 1.

4. Welcome, Interns - Grey's Anatomy Season 19 Episode 1

Welcome, Interns - Grey's Anatomy Season 19 Episode 1
Meredith is tasked with keeping the interns up to scratch, but how difficult a task will that be?

5. What's Next - Grey's Anatomy Season 19 Episode 1

What's Next - Grey's Anatomy Season 19 Episode 1
Meredith has set her sights on a very different career path, which should make for an exciting season ahead.

6. Welcome, Dr. Simone Griffin - Grey's Anatomy Season 19 Episode 1

Welcome, Dr. Simone Griffin - Grey's Anatomy Season 19 Episode 1
Simone Griffin is one of the new doctors at the hospital, and we know she doesn't have the best relationship with the place.

7. A Teaching Hospital Again - Grey's Anatomy Season 19 Episode 1

A Teaching Hospital Again - Grey's Anatomy Season 19 Episode 1
Amelia will play a big part in bringing the hospital back to its former glory. How far will she go?

8. Talking It Out - Grey's Anatomy Season 19 Episode 1

Talking It Out - Grey's Anatomy Season 19 Episode 1
With a time jump in the cards, it's possible the new interns already have relationships with the legacy characters.

9. A New Start - Grey's Anatomy Season 19 Episode 1

A New Start - Grey's Anatomy Season 19 Episode 1
The hospital is embracing the change, and that can only mean one thing: New characters!

10. Weber's New Friend - Grey's Anatomy Season 19 Episode 1

Weber's New Friend - Grey's Anatomy Season 19 Episode 1
There's a lot of change in the hospital, but how will Weber react to them?

11. Amelia's New Trajectory - Grey's Anatomy Season 19 Episode 1

Amelia's New Trajectory - Grey's Anatomy Season 19 Episode 1
Amelia has experienced a lot of growth throughout her time on the series. Now, she's teaching a new wave of doctors.

12. Throwback Thursday - Grey's Anatomy Season 19 Episode 1

Throwback Thursday - Grey's Anatomy Season 19 Episode 1
It looks like the new characters are set to be reminiscent of the original characters, and we are so here for it.

13. Less Than Impressed - Grey's Anatomy Season 19 Episode 1

Less Than Impressed - Grey's Anatomy Season 19 Episode 1
Jules and Mika look to be getting off to a bad start with each other.

14. Ready for the Fresh Start - Grey's Anatomy Season 19 Episode 1

Ready for the Fresh Start - Grey's Anatomy Season 19 Episode 1
Adding five new interns into the mix will undoubtedly shake up the show's dynamics like never before.

15. Niko Terho ad Lucas Adams - Grey's Anatomy Season 19 Episode 1

Niko Terho ad Lucas Adams - Grey's Anatomy Season 19 Episode 1
Niko Terho joins the cast as Lucas Adams on Grey's Anatomy Season 19.

16. Midori Francis as Dr. Mila Yasuda - Grey's Anatomy Season 19 Episode 1

Midori Francis as Dr. Mila Yasuda - Grey's Anatomy Season 19 Episode 1
Midori Francis joins the cast as Dr. Mila Yasuda for Grey's Anatomy Season 19.

17. Drama for the Interns - Grey's Anatomy Season 19 Episode 1

Drama for the Interns - Grey's Anatomy Season 19 Episode 1
The interns will have an uphill battle because the hospital has battled a lot of scrutiny.

18. What Happened? - Grey's Anatomy Season 19 Episode 1

What Happened? - Grey's Anatomy Season 19 Episode 1
The teaser hints that Jules had a night of passion with one of the other doctors. Should we expect rumors to be running rampant?

19. Best Friends - Grey's Anatomy Season 19 Episode 1

Best Friends - Grey's Anatomy Season 19 Episode 1
Link and Jo have been great friends in the past. How will they navigate that in Season 19?

20. Making Strides - Grey's Anatomy Season 19 Episode 1

Making Strides - Grey's Anatomy Season 19 Episode 1
There are big changes ahead, and we can't wait to see what happens.

21. Jo Makes a Plan - Grey's Anatomy Season 19 Episode 1

Jo Makes a Plan - Grey's Anatomy Season 19 Episode 1
Jo followed a new career path on Season 18, so there will be some big changes.

22. What's Next for Link - Grey's Anatomy Season 19 Episode 1

What's Next for Link - Grey's Anatomy Season 19 Episode 1
Link has some big decisions to make on Grey's Anatomy Season 19.

23. Talking Outside the Hospital - Grey's Anatomy Season 19 Episode 1

Talking Outside the Hospital - Grey's Anatomy Season 19 Episode 1
There are some conversations to be had on Grey's Anatomy Season 19.

Wait! There's more! Just click "Next" below:

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Grey's Anatomy Season 19 Episode 1: "Everything Has Changed"
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Grey's Anatomy Season 19 Episode 1 Quotes

I hate it. I hate it so much. You need senior surgical residents. I may go as far as to say you need a chief resident. And if you make me him, I will be mean. I will be bossy. And if I'm ever tempted to go soft, I would picture a return to OB, and I will get stronger. Stronger like a vagina, which I've been forced to learn can stretch to 200 times its natural size and lift a 30lb weight just by flexing. I'll be the vagina of the program if you'll let me.

Levi

Amelia: Derek was a god to him.
Mer: I know.
Amelia: And Lucas was Derek's favorite nephew, and I do love him, so I hate to keep saying this, but I don't think he has what it takes.
Mer: I know you don't.
Amelia: He's a mess. He doesn't follow instructions. He has to do everything he own way. Did you hire him because he reminds you of Derek?
Mer: Not Derek. He is a mess. He does need to do things his own way. But he does have a stroke of the family genius, and he's a bit of a black sheep. You don't see it, do you?
Amelia: Is that why he drives me crazy? He's me.
Mer: Yes, he's you. He's got the spark. He's got the drive. He just needs a chance.