Reshma Shetty is Indian and grew up in both England and Virginia. She attended James Madison University as a pre-med major, but switched her major and graduated with a B.A. in opera performance. She then attended University of Kentucky, where she received her Master's Degree of Music. After, she attended the Cincinnati Conservatory of Music and earned her artist diploma in opera.
Before landing on of the lead roles of Royal Pains as Divya Katdare, Reshma appeared in Steam and 30 Rock.
She has also been in the shows Bombay Dreams and Rafta Rafta.