George - who's gentle, shy personality already jeopardizes his manhood - is not enjoying his "sister" role while living with Meredith and Izzie. The ladies walk in on him showering, ask him to buy tampons and look at him as anything but a desirable member of the opposite sex.
Cristina, on the other hands, has her main desire of the day in mind: she arrives before all other interns in order to get the case of a former nurse at the hospital who is dying of pancreatic cancer. Cristina wants to be in on the whipple surgery.
Meanwhile, Alex has taken too referring to Izzie as "Dr. Model" because she posed in magazines to pay her way through college. The teasing is taken too far, however, when Alex makes countless copies of an ad of Izzie in her undies. He circulates it around the locker room and Izzie responds by stripping herself down, asking everyone if they've gotten their chauvinist fill and then reminding them that she won't be paying off student loans for years thanks to her previous side career. Game, set, match, Dr. Model.
Meredith and Sheppard then square off professionally for the first time. She believes that a construction worker with nails in his head also has the misfortune of a tumor. He and his wife can choose to operate and extend his life, but cost him memories and personality; or, they can leave the tumor alone and having few, real years together. The couple chooses the former and Meredith, sick, forgetful mother on her mind, oversteps her boundaries by berating the wife for her decision.
Despite the disagreement, Meredith meets Sheppard for breakfast the next day. Another love flower could be blooming as Burke is there to comfort Meredith after the retired nurse passes away