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The show premise is introduced via a television show that a synthetic blood, Tru Blood, has been introduced that will allow Vampires to live amongst the living in society.  Sookie Stackhouse, a waitress at a local bar, Merlotte's, in Louisiana, has the ability to read minds and meets a vampire, Bill, who comes in as a customer.  Sookie ends up saving the vampire's life from a couple of locals, that end up jumping her at the end of the episode.  Meanwhile, Sookie's brother, Jason, ends up sleeping with a woman with a weird vampire fetish that turns up dead that night and is suspected by the town and cops.  Sookie's best friend, Tara, quits her job and ends up working at Merlotte's.

True Blood
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True Blood Season 1 Episode 1 Quotes

Grandma [about people charging vampires for sex]: Wonder how much one would charge for something like that?
Jason: A thousand bucks.
Sookie: See, now that just makes me sick.
Grandma: I know. What kind of cheap woman could ever do something like that?
Sookie: No it makes me sick that they're getting a thousand bucks to lay there and do nothing while I bust my ass for ten bucks an hour plus tips

Tara [tending bar]: Uh-oh do... do not snap at me. I have a name. And that name is Tara. Isn't that funny a black girl being named after a plantation. No I don't think it's funny at all. In fact it really pisses me off that my momma was either stupid or just plain mean. Which is why you better be nice if you plan on getting a drink tonight.
Customer: Sorry