Dr. Venture is offered a job by theme park owner, Roy Brisby.  The brothers end up with the Organge County Liberation Front, a group devoted to taking down Mr. Brisby.

Venture Brothers
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Venture Brothers Season 1 Episode 4 Quotes

Dr. Venture: Hey! Where do you get off?! You don't know me!
Mr. Brisby: Oh, I know you, Dr. Venture. My researchers are very thorough. For instance you're not actually a doctor of anything. You never finished school. I also know that since you took over Venture Industries, profits have gone...zippidy-do-da

Mr. Brisby: I need you to clone me, Dr. Venture! That I might live to see my dream fulfilled. This dried old husk of mine might be broken and used up, but my brain is as alert and alive as the day I scribbled my first Bizzy Bee. Got it?
Dr. Venture: Oh, no no no. What I just got is that you're like a total jacked up freaky-deaky crazy pants!