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Izzie left because KH asked for a 5 week leave to shoot her new movie. That's probably why she was fired on Grey's, to justify her absence on the show...
Maybe not the best storyline, but she's still on the show...
- Gizzie as a couple (didn't work out imo)
- Addisex (just a fling and felt so sorry for Mark, he was behaving good for her and she had sex with Alex..)
- Derek and Rose (she was too suggary and turn out to be a real bit**)
- Slexie (just yuck! Make me not like Mark that much and he's one of my fav)
- Mark and Callie
- Mark and Derek
- Bailey and Addison
- Callie and Addison
- Mer and Alex