A couple of thoughts..different from the first 2 seasons..
A cool location would be to base it in a coal mine or oil refinery..somewhere that is isolated or underground. The workers and their families would be living in that area but somewhat removed from civilization. An inspector is called to investigate all the mysterious events and the inspector and his/her family become the central characters. Maybe there was a mass grave in that area or the mine owners' ancestors let a lot of workers die due to negligence or personal gain. An added twist would be to base it about 100 or so years in the past, during the industrial revolution or world war 1.
Another suggestion would be to have a cast of a movie shooting (on an island or a desert for added effect) and being on a movie set over a 2-3 month period and some cast members have a dark past. Weird things can happen while filming and some secrets are not revealed until the end when the editor is reviewing the tapes.