She was nominated for Grammy Awards for Best Comedy Album for Live (2014) and Boyish Girl Interrupted (2017) and an Emmy Award for Outstanding Writing for a Variety Special for Tig Notaro: Boyish Girl Interrupted (2016).
Notaro played Commander Jett Reno on the Paramount+ series Star Trek: Discovery (2019-2022).
She can currently be seen as Amanda Robinson on the AppleTV+ series The Morning Show.