Trio of Guest Stars Lined Up For Season 5 Opener

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Dr. Bailey and the gang — but mainly Bailey — will have their hands full in the two-hour Grey's Anatomy Season Five premiere, TV Guide reports.

Why? A trio of gal pals of a certain age descends on Seattle Grace.

In the September 25 episode, Bernadette Peters, Mariette Hartley and Kathy Baker will guest star as friends who each require the hospital's care.

This comes the very same night that Jeffrey Dean Morgan reprises his role of Denny Duquette, although our guess is that is a separate story line.

Free Clinic

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Grey's Anatomy Quotes

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."