Does Izzie have cancer on Grey's Anatomy? When will we know?
How will the Alex-Izzie relationship progress amid her ailing diagnosis?
Is Izzie going to die to make way for Katherine Heigl's long-desired exit?
Does a casting call for a trailer-park woman in her 40s-50s for the penultimate episode of the season mean Izzie's mom is coming to Seattle Grace - possibly to take her daughter home?
Follow the link to get the latest on all these Grey's Anatomy spoilers ...