Considering the fact that the show's main character is in a mental institution, it might seem like a no-brainer to say that changes will abound on season six of House.

But executive producer Katie Jacobs gets more specific in a recent talk with Michael Ausiello, telling the Entertainment Weekly columnist that Princeton Plainsboro will look different in the fall.

"How [the hospital] works when he comes back will be different," said Jacobs. "A doctor can't check into a mental institution and just walk back into his job like nothing happened. We will not start forsaking reality. This [story] will have consequences."

One thing that won't change, however, is the basic ignoring of Chase and Cameron's private life, Jacobs added.

"I don't know that we will show any more of their private lives that we have anyone else's. The hospital stuff is first and foremost for us and everything we show furthers those storylines. I don't think love-dovey, at-home relations is what people watch our show for."

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.